Research

Peer reviewed publications

1. Ulutekin, C., Galli, E., Schreiner, B., Khademi, M., Callegari, I., Piehl, F., Sanderson, N., Kirschenbaum, D., Mundt, S., Filippi, M., Furlan, R., Olsson, T., Derfuss, T., Ingelfinger, F., & Becher, B. (2024). B cell depletion attenuates CD27 signaling of T helper cells in multiple sclerosis. Cell reports. Medicine, 5(1), 101351. https://doi.org/10.1016/j.xcrm.2023.101351

2. Andreadou, M.; Ingelfinger, F.; De Feo, D.; Friebel, E.; Tuzlak, S.; Cramer, T. M. L.; Schreiner, B.; Eede, P.; Schneeberger, S.; Geesdorf, M.; Ridder, F.; Welsh, C.; Kirschenbaum, D.; Tyagarajan, S. K.; Greter, M.; Heppner, F. L.; Mundt, S.*; Becher, B.* Neuroprotective Tissue Adaptation Induced by IL-12 Attenuates CNS Inflammation. Nature Neuroscience 2023. doi.org/10.1038/s41593-023-01435-z *Shared last authorship, I conceptualized the study, supervised the PhD student, wrote the manuscript, and secured funding

3. Nuñez, N. G., Schmid, J., Power, L., Alberti, C., Krishnarajah, S., Kreutmair, S., Unger, S., Blanco, S., Konigheim, B., Marín, C., Onofrio, L., Kienzler, J. C., Costa-Pereira, S., Ingelfinger, F., InmunoCovidCba, InViV working group, Pasinovich, M. E., Castelli, J. M., Vizzotti, C., Schaefer, M., … Becher, B. (2023). High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity. Nature immunology, 10.1038/s41590-023-01499-w. Advance online publication. https://doi.org/10.1038/s41590-023-01499-w

4. Ingelfinger, F., Kramer, M., Lutz, M., Widmer, C. C., Piccoli, L., Kreutmair, S., Wertheimer, T., Woodhall, M., Waters, P., Sallusto, F., Lanzavecchia, A., Mundt, S., Becher, B., & Schreiner, B. (2023).  Antibodies Produced by CLL Phenotype B Cells in Patients With Myasthenia Gravis Are Not Directed Against Neuromuscular Endplates. Neurology(R) neuroimmunology & neuroinflammation, 10(2), e200087. https://doi.org/10.1212/NXI.0000000000200087 doi:10.1212/NXI.0000000000200087. 

5. Mundt, S., Greter, M., & Becher, B. (2022). The CNS mononuclear phagocyte system in health and disease. Neuron, 110(21), 3497–3512. https://doi.org/10.1016/j.neuron.2022.10.005. First authorship; I conceptualized and wrote the manuscript

6. Ingelfinger, F., Sparano, C., Bamert, D., Reyes-Leiva, D., Sethi, A., Rindlisbacher, L., Zwicky, P., Kreutmair, S., Widmer, C. C., Mundt, S., Cortés-Vicente, E., Tugues, S., Becher, B., & Schreiner, B. (2022). Azathioprine therapy induces selective NK cell Depletion and IFN-γ Deficiency predisposing to herpes virus reactivation. The Journal of allergy and clinical immunology, S0091-6749(22)01187-3. Advance online publication. https://doi.org/10.1016/j.jaci.2022.09.010. Co-authorship; Mentorship of the PhD student, providing intellectual input for the experimental approach and data analysis, critical review of the manuscript

7. Ingelfinger, F., Gerdes, L. A., Kavaka, V., Krishnarajah, S., Friebel, E., Galli, E., Zwicky, P., Furrer, R., Peukert, C., Dutertre, C. A., Eglseer, K. M., Ginhoux, F., Flierl-Hecht, A., Kümpfel, T., De Feo, D., Schreiner, B., Mundt, S., Kerschensteiner, M., Hohlfeld, R., Beltrán, E., … Becher, B. (2022). Twin study reveals non-heritable immune perturbations in multiple sclerosis. Nature, 603(7899), 152–158. https://doi.org/10.1038/s41586-022-04419-4 Co-authorship; Mentorship of the PhD student, providing intellectual input for the experimental approach and revised the manuscript

8. Krishnarajah, S., Ingelfinger, F., Friebel, E. et al. Single-cell profiling of immune system alterations in lymphoid, barrier and solid tissues in aged mice. Nat Aging 2, 74–89 (2022). https://doi.org/10.1038/s43587-021-00148-x

9. Zwicky, P., Ingelfinger, F., Silva de Melo, B. M., Ruchti, F., Schärli, S., Puertas, N., Lutz, M., Phan, T. S., Kündig, T. M., Levesque, M. P., Maul, J. T., Schlapbach, C., LeibundGut-Landmann, S., Mundt, S. *, & Becher, B. * (2021). IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation. Science immunology, 6(64), eabg9012. https://doi.org/10.1126/sciimmunol.abg9012 *Shared last authorship; I conceptualized the study, supervised the PhD student, revised the manuscript and secured funding

10. Ingelfinger, F., Krishnarajah, S., Kramer, M., Utz, S. G., Galli, E., Lutz, M., Zwicky, P., Akarca, A. U., Jurado, N. P., Ulutekin, C., Bamert, D., Widmer, C. C., Piccoli, L., Sallusto, F., Núñez, N. G., Marafioti, T., Schneiter, D., Opitz, I., Lanzavecchia, A., Jung, H. H., … Becher, B. (2021). Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature. Acta neuropathologica, 141(6), 901–915. https://doi.org/10.1007/s00401-021-02299-y. Co-authorship; Mentorship of the PhD student, providing intellectual input for the experimental approach and data analysis and revised the manuscript

11. Mundt, S., Keller, A., & Greter, M. (2021). The dural sinus hub: more than just a brain drain. Cell, 184(4), 858–860. https://doi.org/10.1016/j.cell.2021.01.040

12. Keller, C. W., Kotur, M. B., Mundt, S., Dokalis, N., Ligeon, L. A., Shah, A. M., Prinz, M., Becher, B., Münz, C., & Lünemann, J. D. (2021). CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation. Autophagy, 17(5), 1244–1258. https://doi.org/10.1080/15548627.2020.1756678 Co-authorship; Performed high-dimensional flow cytometry and data analysis of the steady state brain cDC compartment

13. Phan, T. S., Schink, L., Mann, J., Merk, V. M., Zwicky, P., Mundt, S., Simon, D., Kulms, D., Abraham, S., Legler, D. F., Noti, M., & Brunner, T. (2021). Keratinocytes control skin immune homeostasis through de novo-synthesized glucocorticoids. Science advances, 7(5), eabe0337. https://doi.org/10.1126/sciadv.abe0337. Co-authorship; Providing intellectual input for the experimental approach and data analysis and revised the manuscript

14. Mundt, S., Greter, M., Flügel, A., & Becher, B. (2019). The CNS Immune Landscape from the Viewpoint of a T Cell. Trends in neurosciences, 42(10), 667–679. https://doi.org/10.1016/j.tins.2019.07.008. First authorship; I conceptualized and wrote the manuscript

15. Mundt, S., Mrdjen, D., Utz, S. G., Greter, M., Schreiner, B., & Becher, B. (2019). Conventional DCs sample and present myelin antigens in the healthy CNS and allow parenchymal T cell entry to initiate neuroinflammation. Science immunology, 4(31), eaau8380. https://doi.org/10.1126/sciimmunol.aau8380. First authorship; I planned and performed all experiments, analyzed the data and wrote the manuscript

16. Keller, C. W., Sina, C., Kotur, M. B., Ramelli, G., Mundt, S., Quast, I., Ligeon, L. A., Weber, P., Becher, B., Münz, C., & Lünemann, J. D. (2017). ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation. Proceedings of the National Academy of Sciences of the United States of America, 114(52), E11228–E11237. https://doi.org/10.1073/pnas.1713664114. Co-authorship; Performed high-dimensional flow cytometry and data analysis of the steady state brain cDC compartment

17. Basler, M., Mundt, S., & Groettrup, M. (2018). The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire. European journal of immunology, 48(3), 419–429. https://doi.org/10.1002/eji.201747282

18. Mundt, S., Basler, M., Sawitzki, B., & Groettrup, M. (2017). No prolongation of skin allograft survival by immunoproteasome inhibition in mice. Molecular immunology, 88, 32–37. https://doi.org/10.1016/j.molimm.2017.05.022. First authorship; I planned and performed all experiments, analyzed the data and wrote the manuscript

19. Mundt, S., Basler, M., Buerger, S., Engler, H., & Groettrup, M. (2016). Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice. Scientific reports, 6, 19434. https://doi.org/10.1038/srep19434. First authorship; I planned and performed all experiments, analyzed the data and wrote the manuscript

20. Buerger, S., Herrmann, V. L., Mundt, S., Trautwein, N., Groettrup, M., & Basler, M. (2015). The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection. Journal of immunology (Baltimore, Md. : 1950), 195(9), 4106–4116. https://doi.org/10.4049/jimmunol.1500592

21. Mundt, S., Groettrup, M., & Basler, M. (2015). Analgesia in mice with experimental meningitis reduces pain without altering immune parameters. ALTEX, 32(3), 183–189. https://doi.org/10.14573/altex.1502021. First authorship; I planned and performed all experiments, analyzed the data and wrote the manuscript

22. Mundt, S., Engelhardt, B., Kirk, C. J., Groettrup, M., & Basler, M. (2016). Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis. European journal of immunology, 46(1), 104–113. https://doi.org/10.1002/eji.201545578. First authorship; I planned and performed all experiments, analyzed the data and wrote the manuscript

23. Basler, M., Mundt, S., Bitzer, A., Schmidt, C., & Groettrup, M. (2015). The immunoproteasome: a novel drug target for autoimmune diseases. Clinical and experimental rheumatology, 33(4 Suppl 92), S74–S79. Co-authorship; I conceptualized and wrote a part of the manuscript

24. Basler, M.*, Mundt, S.*, Muchamuel, T.*, Moll, C., Jiang, J., Groettrup, M., & Kirk, C. J. (2014). Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis. EMBO molecular medicine, 6(2), 226–238. https://doi.org/10.1002/emmm.201303543. *Shared first authorship; I planned and performed experiments, analyzed the data and wrote the manuscript

Preprints & in revision

1. Costa-Pereira, S., Lanzinger, M., Andreadou, M., Nunez, N., Villar-Vesga, J., Prisco, F., Hane, P., Roussel, E., Krishnarajah, S., Lindemann, R. C., Westermann, F., Oberbichler, L., Sethi, A., Fonseca, A., Pinzger, M., Tugues, S., Mundt, S., Kipar, A., Greter, M., … Becher, B. (2024). Regulatory T cells control type 1-driven immunopathology restraining GM-CSF-producing helper T cells. bioRxiv. https://doi.org/10.1101/2024.01.24.577048

2. “Multimodal transcriptomics reveal neurogenic aging trajectories and the emergence of regional inflammation in the aging mouse dentate gyrus.”, in revision in Nature Neuroscience

3. “IL-34-dependent perivascular macrophages support the integrity of the blood-brain barrier”, in revision in Immunity